When trying to determine the possible solutions to treat vexing diseases, it is critical to have an understanding of the underlying mechanisms or pathophysiology of the disease process. This study can range from the visual inspection of damaged organs to the molecular and cellular level.

Scientists from the Salk Institute for Biological Studies and the Scripps Research Institute reported in the August 10, 2010 issue of the journal Science reported progress in understanding how aging contributes to the development of Alzheimer Disease. The story in itself is fascinating and paints a wonderful picture of how basic science in an area that would seem completely unrelated to human neurodegenerative disease has made an important contribution to understanding the cause of Alzheimer Disease.

• Dr. Andrew Dillin, Ph.D., Pioneer Developmental Chair and assistant professor at The Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory.