The mechanism of why statin medications can cause muscles aches has been outlined but this pathway is found in a minority of patients so other reasons remain elusive.

Medical Mythbusting Commentary for June 3, 2026

Source:
A Painful Side Effect of Statins Explained After Decades of Mystery

Reference:
Structural basis for simvastatin-induced skeletal muscle weakness associated with type 1 ryanodine receptor T4709M mutation