New insight into how HIV destroys the immune system leads to drug that partially blocks the process: more clinical studies required

Dr. Barry Dworkin

Madely Health Headlines Commentary for December 23, 2013

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Source:

New AIDS treatment? Experimental drug blocks HIV from killing immune system cells in lab test

Reference:

  1. Gilad Doitsh, Nicole L. K. Galloway, Xin Geng, Zhiyuan Yang, Kathryn M. Monroe, Orlando Zepeda, Peter W. Hunt, Hiroyu Hatano, Stefanie Sowinski, Isa Muñoz-Arias, Warner C. Greene. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature, 2013; DOI:10.1038/nature12940
  2. K. M. Monroe, Z. Yang, J. R. Johnson, X. Geng, G. Doitsh, N. J. Krogan, W. C. Greene. IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV. Science, 2013; DOI: 10.1126/science.1243640

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  3. HIV vaccine hopes should not be “dashed” by trial failure. Results contribute to understanding and formulating new approaches. We learn from our mistakes and failures in order to attain our goals.
  4. Study in Nature outlines how in vitro and in vivo (mouse model), specific white blood cells (B-Cells) can be genetically programmed to produce anti-HIV antibodies thus offer a one-time treatment for the disease. Long way to go but elegant study design.