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Researchers say modified version of CBD could help reverse fentanyl effects noted in in vitro trials. Much to be done to determine if it will progress to animal models and eventually testing in human trials.
Medical Mythbusting Commentary for July 21, 2023 Source:Researchers say modified version of CBD could help reverse fentanyl effects Reference:Structure–Activity Relationship Study of Cannabidiol-Based Analogs as Negative Allosteric Modulators of the μ-Opioid Receptor
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Scientists use AI to discover antibiotic for ‘very difficult to treat’ bacteria
Medical Mythbusting Commentary for May 26, 2023 Source:Scientists use AI to discover antibiotic for ‘very difficult to treat’ bacteria Reference:Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii
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Epigenetic processes seem to be intimately involved in the cellular aging process. Research uncovering the mechanisms of these processes may help reverse the harm from degenerative disease among other conditions.
Medical Mythbusting Commentary for February 10, 2023 Source:Researchers May Have Found a Way to Slow Human Aging Reference:Loss of epigenetic information as a cause of mammalian agingReprogramming to recover youthful epigenetic information and restore vision
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Pretty cool! Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia (in mice).
Medical Mythbusting Commentary for September 27, 2022 Source:Tiny swimming robots treat deadly pneumonia in mice Reference:Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia
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Tweaking CAR-T activity with on/off switches may reduce cytokine release syndrome.
Medical Mythbusting Commentary for September 12, 2022 Source:Immune cells engineered to battle cancer can be turned ‘on’ or ‘off’ Reference:High-performance multiplex drug-gated CAR circuits
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Study succeeds at restoring selected molecular and cellular processes across multiple vital organs after death in pigs. Far from human use and a plethora of bioethical questions remain to be addressed.
Medical Mythbusting Commentary for August 4, 2022 Source:NYT A ‘Reversible’ Form of Death? Scientists Revive Cells in Dead Pigs’ Organs. Reference:Cellular recovery after prolonged warm ischaemia of the whole body
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Study in Nature outlines how in vitro and in vivo (mouse model), specific white blood cells (B-Cells) can be genetically programmed to produce anti-HIV antibodies thus offer a one-time treatment for the disease. Long way to go but elegant study design.
Medical Mythbusting Commentary for June 15, 2022 Source:A “One-Time” Treatment for HIV Could Be on the Horizon Reference:In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice
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Early days but nonetheless intriguing; UBC scientists discover how to 3D print testicular cells
Medical Mythbusting Commentary for March 25, 2022 Source:UBC scientists discover how to 3D print testicular cells