New insight into how HIV destroys the immune system leads to drug that partially blocks the process: more clinical studies required

Madely Health Headlines Commentary for December 23, 2013


New AIDS treatment? Experimental drug blocks HIV from killing immune system cells in lab test


  1. Gilad Doitsh, Nicole L. K. Galloway, Xin Geng, Zhiyuan Yang, Kathryn M. Monroe, Orlando Zepeda, Peter W. Hunt, Hiroyu Hatano, Stefanie Sowinski, Isa Muñoz-Arias, Warner C. Greene. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infectionNature, 2013; DOI:10.1038/nature12940
  2. K. M. Monroe, Z. Yang, J. R. Johnson, X. Geng, G. Doitsh, N. J. Krogan, W. C. Greene. IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIVScience, 2013; DOI: 10.1126/science.1243640